In vitro activity of daptomycin against gram-positive European clinical isolates with defined resistance determinants

Antimicrob Agents Chemother. 2004 Mar;48(3):1007-11. doi: 10.1128/AAC.48.3.1007-1011.2004.

Abstract

The in vitro activity of daptomycin against 337 gram-positive European clinical isolates with known resistance genes was determined. The MIC ranges for Staphylococcus aureus, enterococci, pneunococci, and streptococci were 0.03 to 1, 0.25 to 8, 0.12 to 1, and 0.06 to 8 micro g/ml, respectively. For only one streptococcus isolate and seven enterococcus isolates was the MIC 8 micro g/ml.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • DNA Primers
  • DNA, Bacterial / genetics
  • Daptomycin / pharmacology*
  • Drug Resistance, Bacterial / genetics
  • Europe
  • Gram-Positive Bacteria / drug effects*
  • Gram-Positive Bacteria / genetics*
  • Gram-Positive Bacterial Infections / microbiology
  • Humans
  • Microbial Sensitivity Tests
  • Phenotype
  • Reverse Transcriptase Polymerase Chain Reaction

Substances

  • Anti-Bacterial Agents
  • DNA Primers
  • DNA, Bacterial
  • Daptomycin