Abstract
We evaluated acute hematological and long-term pulmonary toxicity of radioimmunotherapy in murine models of Cryptococcus neoformans infection. Activities up to 250 microCi were well tolerated by healthy A/JCr mice for (213)Bi-18B7 and (188)Re-18B7 monoclonal antibodies. In infected mice, doses up to 150 microCi produced only transient toxicity. The lungs of treated mice had no evidence of radiation fibrosis.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal / therapeutic use
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Bismuth
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Blood Cell Count
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Cryptococcosis / blood
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Cryptococcosis / radiotherapy*
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Female
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Fibrosis
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Hematologic Diseases / blood*
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Hematologic Diseases / etiology*
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Lung / pathology
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Lung Diseases / pathology*
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Mice
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Mice, Inbred A
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Platelet Count
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Radioimmunotherapy / adverse effects*
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Radioisotopes / therapeutic use
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Rhenium
Substances
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Antibodies, Monoclonal
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Radioisotopes
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Rhenium
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Bismuth