Evaluation of acute hematologic and long-term pulmonary toxicities of radioimmunotherapy of Cryptococcus neoformans infection in murine models

Antimicrob Agents Chemother. 2004 Mar;48(3):1004-6. doi: 10.1128/AAC.48.3.1004-1006.2004.

Abstract

We evaluated acute hematological and long-term pulmonary toxicity of radioimmunotherapy in murine models of Cryptococcus neoformans infection. Activities up to 250 microCi were well tolerated by healthy A/JCr mice for (213)Bi-18B7 and (188)Re-18B7 monoclonal antibodies. In infected mice, doses up to 150 microCi produced only transient toxicity. The lungs of treated mice had no evidence of radiation fibrosis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / therapeutic use
  • Bismuth
  • Blood Cell Count
  • Cryptococcosis / blood
  • Cryptococcosis / radiotherapy*
  • Female
  • Fibrosis
  • Hematologic Diseases / blood*
  • Hematologic Diseases / etiology*
  • Lung / pathology
  • Lung Diseases / pathology*
  • Mice
  • Mice, Inbred A
  • Platelet Count
  • Radioimmunotherapy / adverse effects*
  • Radioisotopes / therapeutic use
  • Rhenium

Substances

  • Antibodies, Monoclonal
  • Radioisotopes
  • Rhenium
  • Bismuth