Syntheses and biological evaluation of new fluoroquinolone antibacterials containing chiral oxiimino pyrrolidine

Bioorg Med Chem Lett. 2004 Mar 8;14(5):1273-7. doi: 10.1016/j.bmcl.2003.12.044.

Abstract

The design and syntheses of new fluoroquinolone antibacterial agents having pyrrolidine ring at C-7 position are described. The pyrrolidine ring is optically active and possesses methyloxime functional group. Two of them have excellent in vitro antibacterial activities and pharmacokinetic profiles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology
  • Drug Evaluation, Preclinical / methods
  • Fluoroquinolones / chemical synthesis*
  • Fluoroquinolones / pharmacology
  • Microbial Sensitivity Tests / statistics & numerical data
  • Pyrrolidines / chemical synthesis*
  • Pyrrolidines / pharmacology
  • Rats
  • Stereoisomerism

Substances

  • Anti-Bacterial Agents
  • Fluoroquinolones
  • Pyrrolidines