Abstract
The design and syntheses of new fluoroquinolone antibacterial agents having pyrrolidine ring at C-7 position are described. The pyrrolidine ring is optically active and possesses methyloxime functional group. Two of them have excellent in vitro antibacterial activities and pharmacokinetic profiles.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Bacterial Agents / chemical synthesis*
-
Anti-Bacterial Agents / pharmacology
-
Drug Evaluation, Preclinical / methods
-
Fluoroquinolones / chemical synthesis*
-
Fluoroquinolones / pharmacology
-
Microbial Sensitivity Tests / statistics & numerical data
-
Pyrrolidines / chemical synthesis*
-
Pyrrolidines / pharmacology
-
Rats
-
Stereoisomerism
Substances
-
Anti-Bacterial Agents
-
Fluoroquinolones
-
Pyrrolidines