Cerebrospinal fluid analysis for Whipple's disease in patients with progressive supranuclear palsy

Mov Disord. 2004 Feb;19(2):220-2. doi: 10.1002/mds.10636.

Abstract

The clinical picture of neurological involvement in Whipple's disease (WD) may resemble progressive supranuclear palsy (PSP). We looked for WD pathogen DNA in the cerebrospinal fluid of 9 patients with a clinical diagnosis of PSP. The analysis was negative for all samples, showing that WD is not commonly involved in the aetiopathogenesis of PSP.

MeSH terms

  • Aged
  • Brain / pathology
  • Cerebrospinal Fluid Proteins / cerebrospinal fluid*
  • DNA, Bacterial / cerebrospinal fluid*
  • Diagnosis, Differential
  • Female
  • Gram-Positive Bacteria / genetics*
  • Gram-Positive Bacterial Infections / cerebrospinal fluid
  • Gram-Positive Bacterial Infections / diagnosis*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neurologic Examination
  • Polymerase Chain Reaction
  • Supranuclear Palsy, Progressive / cerebrospinal fluid
  • Supranuclear Palsy, Progressive / diagnosis*
  • Whipple Disease / cerebrospinal fluid
  • Whipple Disease / diagnosis*

Substances

  • Cerebrospinal Fluid Proteins
  • DNA, Bacterial