Introduction: Paroxysmal activity in medial temporal lobe epilepsy is originated in either hippocampal or parahippocampal regions. This activity can be directly recorded by foramen ovale electrodes. That paroxysmal activity will start from irritative or ictal areas. However, anatomo-functional relations between both regions are still debated.
Objective: We describe a new physical very simple model which allows to directly analysis the anatomo-physiological relations between sources for interictal and ictal areas.
Results: 1) The mathematical model allows to fit with minimum error and great precision the voltage sources originated from monopoles. 2) We can obtain this degree of precision with a matrix using an internodal distance of 0.1 mm (300x200 nodes) 3) Triplets of potentials with double sources with equal or specially with inverse charges have bigger error than monopolar charges. 4) Fitting real data obtained from a patient shows an error of 0.29 +/- 0.17% for interictal and 0.54 +/- 1.22% and 2.84 +/- 3.00% for two seizures (mean +/- SD).
Conclusions: This model allows directly to know the relative anatomo-physiological relations between interictal and ictal sources in MTLE, which have a very important implications so for patho-physiological as therapeutics and outcome implications.