[The preventive activity of monoclonal antibodies specific to the lipopolysaccharide of Francisella tularensis]

V S Khlebnikov; S S Vetchinin; G K Grechko; A A Averina; I R Golovlev; S F Averin; V E Zhemchugov; S I Konovalov; G A Anisimov; S S Afanas'ev

[The preventive activity of monoclonal antibodies specific to the lipopolysaccharide of Francisella tularensis]

Zh Mikrobiol Epidemiol Immunobiol. 1992:(9-10):67-70.

[Article in Russian]

Authors

V S Khlebnikov, S S Vetchinin, G K Grechko, A A Averina, I R Golovlev, S F Averin, V E Zhemchugov, S I Konovalov, G A Anisimov, S S Afanas'ev

PMID: 1481610

Abstract

The preventive activity of five monoclonal antibodies (McAb) in experimental tularemia was evaluated. McAb produced by hybridoma FB11-k (IgG2a), specific to F. tularensis lipopolysaccharide, prevented the death of mice and guinea pigs infected with F. tularensis virulent strain 503 of the holarctic subspecies.

Publication types

Comparative Study

MeSH terms

Animals
Antibodies, Monoclonal / immunology*
Antibodies, Monoclonal / isolation & purification
Antibody Specificity / immunology*
Drug Evaluation, Preclinical
Francisella tularensis / immunology*
Francisella tularensis / pathogenicity
Guinea Pigs
Hybridomas / immunology
Lipopolysaccharides / immunology*
Mice
Mice, Inbred BALB C
Time Factors
Tularemia / immunology
Tularemia / prevention & control*
Virulence / immunology

Substances

Antibodies, Monoclonal
Lipopolysaccharides