Abstract
The more significant bioactivities of a variety of semicarbazones (anti-protozoa, anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and their metal complexes are reviewed together with proposed mechanisms of action and structure-activity relationships. Clinical or potential pharmacological applications of these versatile compounds are discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anti-Infective Agents / pharmacology
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Anticonvulsants / pharmacology
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Antineoplastic Agents / pharmacology
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Organometallic Compounds / pharmacology*
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Radiopharmaceuticals
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Semicarbazones / agonists
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Semicarbazones / pharmacology*
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Thiosemicarbazones / agonists
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Thiosemicarbazones / pharmacology*
Substances
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Anti-Infective Agents
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Anticonvulsants
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Antineoplastic Agents
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Organometallic Compounds
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Radiopharmaceuticals
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Semicarbazones
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Thiosemicarbazones