Abstract
V(D)J recombination assembles antigen receptor genes from component gene segments. We review findings that have shaped our current understanding of this remarkable mechanism, with a focus on two major reports--the first detailed comparison of germline and rearranged antigen receptor loci and the discovery of the recombination activating gene-1.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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B-Lymphocytes / physiology
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Cloning, Molecular
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DNA Damage
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Gene Expression Regulation*
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Genes, RAG-1 / genetics
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Genes, RAG-1 / physiology*
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Humans
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Models, Biological
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Models, Genetic
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Neoplasms / genetics
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Receptors, Antigen
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Recombination, Genetic
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Structure-Activity Relationship
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T-Lymphocytes / physiology
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VDJ Recombinases / metabolism
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VDJ Recombinases / physiology*
Substances
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Receptors, Antigen
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VDJ Recombinases