Unraveling V(D)J recombination; insights into gene regulation

Cell. 2004 Jan 23;116(2):299-311. doi: 10.1016/s0092-8674(04)00039-x.

Abstract

V(D)J recombination assembles antigen receptor genes from component gene segments. We review findings that have shaped our current understanding of this remarkable mechanism, with a focus on two major reports--the first detailed comparison of germline and rearranged antigen receptor loci and the discovery of the recombination activating gene-1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / physiology
  • Cloning, Molecular
  • DNA Damage
  • Gene Expression Regulation*
  • Genes, RAG-1 / genetics
  • Genes, RAG-1 / physiology*
  • Humans
  • Models, Biological
  • Models, Genetic
  • Neoplasms / genetics
  • Receptors, Antigen
  • Recombination, Genetic
  • Structure-Activity Relationship
  • T-Lymphocytes / physiology
  • VDJ Recombinases / metabolism
  • VDJ Recombinases / physiology*

Substances

  • Receptors, Antigen
  • VDJ Recombinases