Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage

Bioorg Med Chem Lett. 2004 Feb 9;14(3):611-4. doi: 10.1016/j.bmcl.2003.11.060.

Abstract

The synthesis of several novel coumarin derivatives with a 7-azomethine linkage was carried out starting from 7-formyl-coumarin. The compounds were tested in vivo for their anti-inflammatory activity and in vitro for their antioxidant ability. Compounds 3a and 3e possess significant protection against carrageenin induced rat paw edema.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Antioxidants / pharmacology*
  • Azo Compounds / chemical synthesis
  • Azo Compounds / pharmacology
  • Carrageenan / toxicity
  • Coumarins / chemical synthesis*
  • Coumarins / pharmacology*
  • Edema / chemically induced
  • Edema / drug therapy
  • Edema / metabolism
  • Hindlimb / drug effects
  • Hindlimb / metabolism
  • Inflammation / chemically induced
  • Inflammation / drug therapy*
  • Inflammation / metabolism
  • Molecular Structure
  • Rats
  • Structure-Activity Relationship

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Azo Compounds
  • Coumarins
  • Carrageenan