Five new maleic and succinic acid derivatives from the mycelium of Antrodia camphorata and their cytotoxic effects on LLC tumor cell line

Norio Nakamura; Akiko Hirakawa; Jiang-Jing Gao; Hiroko Kakuda; Motoo Shiro; Yasuhiro Komatsu; Chia-chin Sheu; Masao Hattori

doi:10.1021/np030293k

Five new maleic and succinic acid derivatives from the mycelium of Antrodia camphorata and their cytotoxic effects on LLC tumor cell line

J Nat Prod. 2004 Jan;67(1):46-8. doi: 10.1021/np030293k.

Authors

Norio Nakamura¹, Akiko Hirakawa, Jiang-Jing Gao, Hiroko Kakuda, Motoo Shiro, Yasuhiro Komatsu, Chia-chin Sheu, Masao Hattori

Affiliation

¹ Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.

PMID: 14738384
DOI: 10.1021/np030293k

Abstract

Five new maleic and succinic acid derivatives were isolated from the mycelium of Antrodia camphorata. Their structures were determined by various spectroscopic means. Maleimide derivatives 2 and 3 showed appreciable cytotoxic activity against LLC cells.

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Maleates / chemistry
Maleates / isolation & purification*
Maleates / pharmacology
Medicine, Chinese Traditional
Molecular Structure
Polyporaceae / chemistry*
Succinic Acid / chemistry
Succinic Acid / isolation & purification*
Succinic Acid / pharmacology
Taiwan
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Maleates
maleic acid
Succinic Acid