Polyoxygenated eudesmanes and trans-chrysanthemanes from the aerial parts of Santolina insularis

J Nat Prod. 2004 Jan;67(1):37-41. doi: 10.1021/np030222l.

Abstract

The eudesmane sesquiterpenoids 1-3 and the trans-chrysanthemyl monoterpenoid 4 have been isolated from the aerial parts of Santolina insularis, a bush endemic to Sardinia. The absolute stereostructures of these novel compounds and of two known but incompletely characterized chrysanthemanes (5, 6) were established by spectroscopic techniques and by application of the modified Mosher method. The presence of the p-menthane aldehyde eucamalol (7) gives credit to the widespread use of S. insularis to fend off mosquitoes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Asteraceae / chemistry*
  • Culicidae / drug effects
  • Eucalyptus / chemistry
  • Italy
  • Molecular Structure
  • Monoterpenes / chemistry
  • Monoterpenes / isolation & purification*
  • Nuclear Magnetic Resonance, Biomolecular
  • Plants, Medicinal / chemistry*
  • Sesquiterpenes, Eudesmane / chemistry
  • Sesquiterpenes, Eudesmane / isolation & purification*
  • Terpenes / chemistry
  • Terpenes / pharmacology

Substances

  • Monoterpenes
  • Sesquiterpenes, Eudesmane
  • Terpenes
  • eucamalol