Saponins from the flower buds of Buddleja officinalis

Hongzhu Guo; Kazuo Koike; Wei Li; Tadaaki Satou; Dean Guo; Tamotsu Nikaido

doi:10.1021/np0300131

Saponins from the flower buds of Buddleja officinalis

J Nat Prod. 2004 Jan;67(1):10-3. doi: 10.1021/np0300131.

Authors

Hongzhu Guo¹, Kazuo Koike, Wei Li, Tadaaki Satou, Dean Guo, Tamotsu Nikaido

Affiliation

¹ Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.

PMID: 14738377
DOI: 10.1021/np0300131

Abstract

Five new saponins, mimengosides C-G (1-5), were isolated from the flower buds of Buddleja officinalis along with five known compounds, namely, songaroside A, acteoside, phenylethyl 2-glucoside, echinacoside, and phenylethyl alcohol 8-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranoside. The structures of 1-5 were elucidated using spectroscopic and chemical methods, and these compounds were evaluated for their inhibitory effects against HL-60 leukemia cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Buddleja / chemistry*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal / chemistry
Drugs, Chinese Herbal / isolation & purification*
Drugs, Chinese Herbal / pharmacology
Flowers / chemistry
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plants, Medicinal / chemistry*
Saponins / chemistry
Saponins / isolation & purification*
Saponins / pharmacology
Stereoisomerism

Substances

Drugs, Chinese Herbal
Saponins