The proteasome and the delicate balance between destruction and rescue

PLoS Biol. 2004 Jan;2(1):E13. doi: 10.1371/journal.pbio.0020013. Epub 2004 Jan 20.

Abstract

The proteasome is a large multiprotein complex that degrades unwanted cellular proteins. The mechanisms that control this protein-eating machine are being uncovered

Publication types

  • Review

MeSH terms

  • Animals
  • Bacterial Proteins / metabolism
  • Metalloproteases / metabolism
  • Models, Biological
  • Proteasome Endopeptidase Complex / metabolism*
  • Ubiquitin / metabolism
  • Ubiquitin-Protein Ligases / metabolism

Substances

  • Bacterial Proteins
  • Ubiquitin
  • Ubiquitin-Protein Ligases
  • Metalloproteases
  • Proteasome Endopeptidase Complex