Abstract
A new indolizinone, namely kinganone (1) together with 3-ethoxymethyl-5,6,7,8-tetrahydro-8-indolizinone (2) and isomucronulatol (3) were isolated from the rhizome of Polygonatum kingianum. Their structures were elucidated mainly on the basis of spectral data. Indolizinones 1 and 2 showed weak antibacterial and antifungal activities when compared to rifampicin and amphotericin, respectively, in the agar diffusion assay.
MeSH terms
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Amphotericin B / pharmacology
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology*
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Bacteria / drug effects*
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Dose-Response Relationship, Drug
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Humans
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Indolizines / chemistry
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Indolizines / pharmacology*
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Microbial Sensitivity Tests
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Penicillium / drug effects
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Phytotherapy*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Polygonatum*
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Rifampin / pharmacology
Substances
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Anti-Infective Agents
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Indolizines
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Plant Extracts
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kinganone
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Amphotericin B
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Rifampin