Abstract
The family of mammalian E-type cyclins is composed of two proteins, termed cyclin E1 and E2. These two cyclins are widely expressed in proliferating cells. E-cyclins bind and activate cyclin dependent kinase CDK2. Cyclin E-CDK2 complexes were believed to play critical function in driving cell cycle progression of normal, nontransformed cells and of cancer cells. Several recent reports challenge this notion.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
CDC2-CDC28 Kinases / deficiency
-
CDC2-CDC28 Kinases / genetics
-
CDC2-CDC28 Kinases / metabolism*
-
Cell Cycle*
-
Cyclin E / deficiency
-
Cyclin E / genetics
-
Cyclin E / metabolism*
-
Cyclin-Dependent Kinase 2
-
Embryo, Mammalian / cytology
-
Embryo, Mammalian / enzymology
-
Embryo, Mammalian / metabolism
-
Gene Deletion
-
Mice
Substances
-
Cyclin E
-
CDC2-CDC28 Kinases
-
Cdk2 protein, mouse
-
Cyclin-Dependent Kinase 2