Effect of Helicobacter pylori eradication on high-density lipoprotein cholesterol

Hubert Scharnagl; Manfred Kist; Andrea Busse Grawitz; Wolfgang Koenig; Heinrich Wieland; Winfried März

doi:10.1016/j.amjcard.2003.09.045

Effect of Helicobacter pylori eradication on high-density lipoprotein cholesterol

Am J Cardiol. 2004 Jan 15;93(2):219-20. doi: 10.1016/j.amjcard.2003.09.045.

Authors

Hubert Scharnagl¹, Manfred Kist, Andrea Busse Grawitz, Wolfgang Koenig, Heinrich Wieland, Winfried März

Affiliation

¹ Clinical Institute of Medical and Chemical Laboratory Diagnostics, University and General Hospital, University of Graz, Graz, Austria. hubert.scharnagl@klinikum-graz.at

PMID: 14715353
DOI: 10.1016/j.amjcard.2003.09.045

Abstract

We examined the effect of Helicobacter pylori (H. pylori) eradication on lipids and apolipoproteins in 87 patients with duodenal ulcers. A significant increase was observed in high-density lipoprotein (HDL) cholesterol (+24.7%, p <0.001), apolipoprotein AI (+9.0%, p <0.001), and apolipoprotein AII (+11.7%, p <0.001) after eradication. Minor increases occurred in total cholesterol, triglycerides, and apolipoprotein B, whereas low-density lipoprotein cholesterol remained unchanged. Our results suggest that chronic H. pylori infection reduces plasma levels of HDL cholesterol and that eradication improves the lipoprotein pattern.

Publication types

Clinical Trial
Multicenter Study
Randomized Controlled Trial

MeSH terms

Apolipoprotein A-I / blood
Apolipoprotein A-II / blood
Apolipoproteins B / blood
Cholesterol, HDL / blood*
Coronary Disease / epidemiology
Drug Therapy, Combination
Duodenal Ulcer / blood
Duodenal Ulcer / microbiology*
Female
Helicobacter Infections / blood
Helicobacter Infections / drug therapy*
Helicobacter pylori* / isolation & purification
Humans
Lipoproteins / blood*
Male
Middle Aged
Retrospective Studies
Risk
Triglycerides / blood

Substances

Apolipoprotein A-I
Apolipoprotein A-II
Apolipoproteins B
Cholesterol, HDL
Lipoproteins
Triglycerides