A new pentacyclic triterpenoid glucoside from Prunus serrulata var. spontanea

Chem Pharm Bull (Tokyo). 2004 Jan;52(1):157-9. doi: 10.1248/cpb.52.157.

Abstract

A new triterpenoid, 2alpha,3alpha,24-trihydroxyurs-12-en-28-oic acid-28-O-beta-D-glucopyranosyl ester (4) along with four known triterpenoids, ursolic acid (1), 2alpha-hydroxyursolic acid (2), 2alpha,3alpha,24-trihydroxyurs-12-en-28-oic acid (3), and 2alpha,3alpha,19alpha,24-tetrahydroxyurs-12-en-28-oic acid-28-O-beta-D-glucopyranosyl ester (5), were isolated from the leaves of Prunus serrulata var. spontanea (Rosaceae). Compounds 3-5 showed ONOO(-) scavenging activity, whereas compounds 1 and 2 were virtually inactive.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / isolation & purification
  • Glycosides / chemistry
  • Glycosides / isolation & purification
  • Magnetic Resonance Spectroscopy
  • Monosaccharides / chemistry*
  • Monosaccharides / isolation & purification
  • Penicillamine / chemistry
  • Peroxynitrous Acid / chemistry
  • Plant Leaves / chemistry
  • Prunus / chemistry*
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spectrophotometry, Infrared
  • Spectroscopy, Fourier Transform Infrared
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification

Substances

  • 2alpha,3alpha,24-trihydroxyurs-12-en-28-oic acid-28-O-beta-D-glucopyranosyl ester
  • Free Radical Scavengers
  • Glycosides
  • Monosaccharides
  • Triterpenes
  • Peroxynitrous Acid
  • Penicillamine