Abstract
Two new diterpenes, named sibiriquinone A (1) and B (2), along with four known diterpenes have been isolated from the aerial part of Veronicastrum sibiricum. Their structures were elucidated by spectroscopy. The isolated compounds showed significant immunosuppressive activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Dexamethasone / pharmacology
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Immunosuppressive Agents / chemistry*
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Immunosuppressive Agents / isolation & purification
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Immunosuppressive Agents / pharmacology*
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In Vitro Techniques
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Lymphocytes / drug effects
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Lymphocytes / immunology
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Molecular Conformation
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Rats
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Scrophulariaceae / chemistry*
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Ultraviolet
Substances
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Diterpenes
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Immunosuppressive Agents
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Dexamethasone