Abstract
A novel naphthanol glycoside, arjunaphthanoloside (1), was isolated from the stem bark of Terminalia arjuna and its structure was established as 2,3,6,7,8,9-hexahydroxynaphthalene-2-O-alpha-L(-)-rhamnoside by means of spectroscopic and chemical methods. Compound 1 showed potent antioxidant activity and inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated rat peritoneal macrophages.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / pharmacology*
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Biphenyl Compounds
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Cardiotonic Agents / pharmacology
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Free Radical Scavengers / pharmacology
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Glycosides / chemistry
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Glycosides / pharmacology*
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Hydrolysis
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In Vitro Techniques
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Lipopolysaccharides / antagonists & inhibitors
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Lipopolysaccharides / pharmacology
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Lipoproteins, LDL / chemistry
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Macrophages, Peritoneal / drug effects
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Macrophages, Peritoneal / metabolism
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Magnetic Resonance Spectroscopy
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Naphthalenes / chemistry
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Naphthalenes / pharmacology*
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Nitric Oxide / antagonists & inhibitors*
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Nitric Oxide Synthase / antagonists & inhibitors
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Nitric Oxide Synthase / metabolism
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Nitric Oxide Synthase Type II
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Picrates / metabolism
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Plant Bark / chemistry
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Plant Extracts / pharmacology
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Rats
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Superoxides / metabolism
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Terminalia / chemistry*
Substances
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Antioxidants
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Biphenyl Compounds
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Cardiotonic Agents
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Free Radical Scavengers
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Glycosides
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Lipopolysaccharides
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Lipoproteins, LDL
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Naphthalenes
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Picrates
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Plant Extracts
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arjunaphthanoloside
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Superoxides
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Nitric Oxide
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1,1-diphenyl-2-picrylhydrazyl
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type II
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Nos2 protein, rat