Post-initiation inhibition of MeIQx hepatocarcinogenesis in rats by cysteine

Osaka City Med J. 2003 Jun;49(1):21-30.

Abstract

Rats were administered cysteine at a dose of 100 mg/kg b.w. 5 times per week after 2-amino-3, 8-dimethylimidazo [4,5-f] quinoxaline (MeIQx) treatment. Significant decrease in numbers and areas of glutathione S-transferase placental form (GST-P)-positive foci, putative preneoplastic lesions, and silver-stained nucleolar organizer regions were evident in the livers of rats treated with cysteine after MeIQx treatment. Morever, post-initiation stage cysteine treatment resulted in decreased hepatic insulin-like growth factor (IGF)-I mRNA expression. Thus post-initiation cysteine treatment may exert chemopreventive effect on MeIQx hepatocarcinogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine
  • Animals
  • Cysteine / pharmacology*
  • DNA / metabolism
  • Deoxyguanosine / analogs & derivatives*
  • Deoxyguanosine / analysis
  • Genes, p53
  • Insulin-Like Growth Factor I / analysis
  • Liver Neoplasms, Experimental / chemically induced
  • Liver Neoplasms, Experimental / prevention & control*
  • Male
  • Nucleolus Organizer Region / drug effects
  • Precancerous Conditions / prevention & control*
  • Quinoxalines / metabolism
  • Quinoxalines / toxicity*
  • Rats
  • Rats, Inbred F344

Substances

  • Quinoxalines
  • Insulin-Like Growth Factor I
  • 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
  • 8-Hydroxy-2'-Deoxyguanosine
  • DNA
  • Deoxyguanosine
  • Cysteine