Abstract
Rats were administered cysteine at a dose of 100 mg/kg b.w. 5 times per week after 2-amino-3, 8-dimethylimidazo [4,5-f] quinoxaline (MeIQx) treatment. Significant decrease in numbers and areas of glutathione S-transferase placental form (GST-P)-positive foci, putative preneoplastic lesions, and silver-stained nucleolar organizer regions were evident in the livers of rats treated with cysteine after MeIQx treatment. Morever, post-initiation stage cysteine treatment resulted in decreased hepatic insulin-like growth factor (IGF)-I mRNA expression. Thus post-initiation cysteine treatment may exert chemopreventive effect on MeIQx hepatocarcinogenesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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8-Hydroxy-2'-Deoxyguanosine
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Animals
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Cysteine / pharmacology*
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DNA / metabolism
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Deoxyguanosine / analogs & derivatives*
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Deoxyguanosine / analysis
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Genes, p53
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Insulin-Like Growth Factor I / analysis
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Liver Neoplasms, Experimental / chemically induced
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Liver Neoplasms, Experimental / prevention & control*
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Male
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Nucleolus Organizer Region / drug effects
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Precancerous Conditions / prevention & control*
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Quinoxalines / metabolism
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Quinoxalines / toxicity*
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Rats
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Rats, Inbred F344
Substances
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Quinoxalines
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Insulin-Like Growth Factor I
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2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
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8-Hydroxy-2'-Deoxyguanosine
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DNA
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Deoxyguanosine
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Cysteine