Preparation of a biodegradable matrix through polyion complex formation by mixing polylactide-based microspheres having oppositely charged surfaces

Hidetoshi Arimura; Yuichi Ohya; Tatsuro Ouchi; Hideaki Yamada

doi:10.1016/j.jcis.2003.10.010

Preparation of a biodegradable matrix through polyion complex formation by mixing polylactide-based microspheres having oppositely charged surfaces

J Colloid Interface Sci. 2004 Feb 15;270(2):299-303. doi: 10.1016/j.jcis.2003.10.010.

Authors

Hidetoshi Arimura¹, Yuichi Ohya, Tatsuro Ouchi, Hideaki Yamada

Affiliation

¹ Faculty of Engineering and High Technology Research Center, Kansai University, Suita, 564-8680 Osaka, Japan. gf2d401@ipcku.kansai-u.ac.jp

PMID: 14697693
DOI: 10.1016/j.jcis.2003.10.010

Abstract

The aggregation of polyions into microsphere (MS) complexes was studied as a preparative method for the construction of a biodegradable matrix. Aqueous suspensions of polylactide (PLA)-based MSs with positively and negatively charged surfaces, MS(K(3)(4+)-PLA) and MS(E(3)(4-)-PLA), respectively, immediately formed aggregates when mixed. The effects of the stoichiometry of the charged groups on the surfaces of the MSs and the ionic strength of the medium on aggregate formation, as well as the degradation behavior of the polyion complex (PIC) matrix over time, were investigated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Absorption
Biocompatible Materials*
Hydrolysis
Ions* / chemistry
Magnetic Resonance Spectroscopy
Mass Spectrometry
Micelles
Microspheres*
Models, Chemical
Polyesters / chemistry*
Time Factors

Substances

Biocompatible Materials
Ions
Micelles
Polyesters
poly(lactide)