Vaccinia virus recombinant expressing gene of tick-borne encephalitis virus non-structural NS1 protein elicits protective activity in mice

M V Khoretonenko; M F Vorovitch; L G Zakharova; G V Pashvykina; N V Ovsyannikova; J R Stephenson; A V Timofeev; A D Altstein; A M Shneider

doi:10.1016/j.imlet.2003.09.002

Vaccinia virus recombinant expressing gene of tick-borne encephalitis virus non-structural NS1 protein elicits protective activity in mice

Immunol Lett. 2003 Dec 15;90(2-3):161-3. doi: 10.1016/j.imlet.2003.09.002.

Authors

M V Khoretonenko¹, M F Vorovitch, L G Zakharova, G V Pashvykina, N V Ovsyannikova, J R Stephenson, A V Timofeev, A D Altstein, A M Shneider

Affiliation

¹ Chumakov Institute of Poliomyelitis and Viral Encephalitides RAMS, Moscow, Russia.

PMID: 14687719
DOI: 10.1016/j.imlet.2003.09.002

Abstract

A vaccinia virus recombinant containing the non-structural tick-borne encephalitis virus (TBEV) NS1 gene was developed. The recombinant expressed native dimeric form of the NS1 protein in infected cells and protected mice against lethal infection with TBEV.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Viral / immunology
Cell Line
Encephalitis Viruses, Tick-Borne / genetics
Encephalitis Viruses, Tick-Borne / immunology*
Encephalitis, Tick-Borne / immunology*
Encephalitis, Tick-Borne / prevention & control*
Encephalitis, Tick-Borne / virology
Mice
Mice, Inbred BALB C
Radioimmunoprecipitation Assay
Survival Rate
Vaccinia virus / genetics*
Viral Nonstructural Proteins / genetics
Viral Nonstructural Proteins / immunology*
Viral Vaccines / immunology

Substances

Antibodies, Viral
NS1 protein, Flavivirus
Viral Nonstructural Proteins
Viral Vaccines