cis-[Pt(NH3)2(L)]2+/+ (L = Cl, H2O, NH3) binding to purines and CO: does pi-back-donation play a role?

Inorg Chem. 2003 Dec 29;42(26):8615-7. doi: 10.1021/ic035022b.

Abstract

The ability of cis-[Pt(NH(3))(2)(L)](2+/+), a molecular fragment of the anticancer drug cisplatin, to bind to purines and CO by pi-back-donation from Pt to the ligand was examined computationally. Optimized geometries and computed vibrational frequencies suggest that cis-[Pt(NH(3))(2)(L)](2+/+) (L = Cl, H(2)O, NH(3)) is a poor pi-donor and that pi-back-donation does not play an important role for Pt(II)-ligand interactions in general.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Carbon Monoxide / chemistry*
  • Carbon Monoxide / metabolism
  • Cisplatin / analogs & derivatives*
  • Cisplatin / chemistry
  • Cisplatin / metabolism
  • Models, Molecular
  • Molecular Structure
  • Organoplatinum Compounds / chemistry*
  • Organoplatinum Compounds / metabolism
  • Purines / chemistry*
  • Purines / metabolism

Substances

  • Organoplatinum Compounds
  • Purines
  • Carbon Monoxide
  • Cisplatin