Abstract
The ability of cis-[Pt(NH(3))(2)(L)](2+/+), a molecular fragment of the anticancer drug cisplatin, to bind to purines and CO by pi-back-donation from Pt to the ligand was examined computationally. Optimized geometries and computed vibrational frequencies suggest that cis-[Pt(NH(3))(2)(L)](2+/+) (L = Cl, H(2)O, NH(3)) is a poor pi-donor and that pi-back-donation does not play an important role for Pt(II)-ligand interactions in general.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Carbon Monoxide / chemistry*
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Carbon Monoxide / metabolism
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Cisplatin / analogs & derivatives*
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Cisplatin / chemistry
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Cisplatin / metabolism
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Models, Molecular
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Molecular Structure
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Organoplatinum Compounds / chemistry*
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Organoplatinum Compounds / metabolism
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Purines / chemistry*
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Purines / metabolism
Substances
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Organoplatinum Compounds
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Purines
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Carbon Monoxide
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Cisplatin