Amino acids as regulators of gene expression: molecular mechanisms

Biochem Biophys Res Commun. 2004 Jan 9;313(2):447-52. doi: 10.1016/j.bbrc.2003.07.020.

Abstract

Regulation of gene expression by nutrients in mammals is an important mechanism allowing them to adapt their physiological functions according to the supply of nutrient in the diet. It has been shown recently that amino acids are able to regulate by themselves the expression of numerous genes. CHOP, asparagine synthetase, and IGFBP-1 regulation following AA starvation will be described in this review with special interest in the molecular mechanisms involved.

Publication types

  • Review

MeSH terms

  • Activating Transcription Factor 4
  • Amino Acids / pharmacology*
  • Amino Acids / physiology*
  • Animals
  • Aspartate-Ammonia Ligase / metabolism
  • CCAAT-Enhancer-Binding Proteins / genetics
  • CCAAT-Enhancer-Binding Proteins / metabolism
  • Dietary Supplements
  • Gene Expression Regulation / drug effects
  • Gene Expression Regulation / physiology*
  • Humans
  • Insulin-Like Growth Factor Binding Protein 1 / metabolism
  • Starvation / metabolism
  • Stress, Physiological / metabolism
  • Transcription Factor CHOP
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transcription, Genetic

Substances

  • ATF4 protein, human
  • Amino Acids
  • CCAAT-Enhancer-Binding Proteins
  • DDIT3 protein, human
  • Insulin-Like Growth Factor Binding Protein 1
  • Transcription Factors
  • Activating Transcription Factor 4
  • Transcription Factor CHOP
  • Aspartate-Ammonia Ligase