Ageladine A: an antiangiogenic matrixmetalloproteinase inhibitor from the marine sponge Agelas nakamurai

Masaki Fujita; Yoichi Nakao; Shigeki Matsunaga; Motoharu Seiki; Yoshifumi Itoh; Jun Yamashita; Rob W M Van Soest; Nobuhiro Fusetani

doi:10.1021/ja038025w

Ageladine A: an antiangiogenic matrixmetalloproteinase inhibitor from the marine sponge Agelas nakamurai

J Am Chem Soc. 2003 Dec 24;125(51):15700-1. doi: 10.1021/ja038025w.

Authors

Masaki Fujita¹, Yoichi Nakao, Shigeki Matsunaga, Motoharu Seiki, Yoshifumi Itoh, Jun Yamashita, Rob W M Van Soest, Nobuhiro Fusetani

Affiliation

¹ Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

PMID: 14677933
DOI: 10.1021/ja038025w

Abstract

A novel MMP inhibitor, ageladine A (1) with antiangiogenic activity was isolated from a marine sponge Agelas nakamurai. Structure 1 was determined by a combination of spectroscopic and chemical methods to be an unprecedented structure of 4-(4,5-dibromo-1H-pyrrol-2-yl)]-1H-imidazo[4,5-c]pyridin-2-amine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry*
Alkaloids / isolation & purification
Alkaloids / pharmacology*
Angiogenesis Inhibitors / chemistry*
Angiogenesis Inhibitors / isolation & purification
Angiogenesis Inhibitors / pharmacology*
Animals
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / isolation & purification
Enzyme Inhibitors / pharmacology*
Matrix Metalloproteinase Inhibitors*
Nuclear Magnetic Resonance, Biomolecular
Porifera / chemistry*
Pyrroles / chemistry*
Pyrroles / isolation & purification
Pyrroles / pharmacology*
Spectrometry, Mass, Fast Atom Bombardment

Substances

Ageladine A
Alkaloids
Angiogenesis Inhibitors
Enzyme Inhibitors
Matrix Metalloproteinase Inhibitors
Pyrroles