A monozygotic conjoined twin pregnancy discordant for laterality of cleft lip

Hideaki Masuzaki; Kiyonori Miura; Ko-ichiro Yoshiura; Shuichiro Yoshimura; Tadayuki Ishimaru

doi:10.1159/000075530

A monozygotic conjoined twin pregnancy discordant for laterality of cleft lip

Gynecol Obstet Invest. 2004;57(2):100-2. doi: 10.1159/000075530. Epub 2003 Dec 11.

Authors

Hideaki Masuzaki¹, Kiyonori Miura, Ko-ichiro Yoshiura, Shuichiro Yoshimura, Tadayuki Ishimaru

Affiliation

¹ Department of Obstetrics and Gynecology, Nagasaki University School of Medicine, Nagasaki, Japan.

PMID: 14671419
DOI: 10.1159/000075530

Abstract

Conjoined twins discordant for phenotype of cleft lip are reported. One had right-sided cleft lip, while the co-twin had left-sided cleft lip. Both twins had a normal 46,XY karyotype. Genotyping at 50 polymorphic loci revealed that the twins were identical (monozygotic). Our analysis suggests that the laterality of cleft lip is more affected by the process of twinning than by genetic factors.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cleft Lip / etiology
Cleft Lip / genetics*
Cleft Lip / pathology
Diseases in Twins / etiology
Diseases in Twins / genetics*
Female
Humans
Pregnancy
Twinning, Monozygotic / physiology
Twins, Conjoined / embryology*
Twins, Conjoined / pathology
Twins, Monozygotic