No replication of the association between the Nicastrin gene and familial early-onset Alzheimer's disease

Neurosci Lett. 2003 Dec 19;353(2):153-5. doi: 10.1016/s0304-3940(03)01105-4.

Abstract

Polymorphisms in the Nicastrin (NCSTN) gene have recently been associated with familial early-onset Alzheimer's disease (AD). The authors genotyped four NCTSN polymorphisms in a large cohort of 489 AD cases (including 158 sporadic early-onset AD cases and 95 familial early-onset AD cases) and 386 controls but failed to replicate the association between NCSTN haplotype B and AD.

Publication types

  • Comparative Study

MeSH terms

  • Age of Onset
  • Aged
  • Alzheimer Disease / genetics*
  • Amyloid Precursor Protein Secretases
  • Apolipoprotein E4
  • Apolipoproteins E / genetics
  • France
  • Gene Frequency
  • Genotype
  • Haplotypes
  • Humans
  • Membrane Glycoproteins / genetics*
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide

Substances

  • Apolipoprotein E4
  • Apolipoproteins E
  • Membrane Glycoproteins
  • nicastrin protein
  • Amyloid Precursor Protein Secretases