Five newly identified HLA alleles: A*0310, A*2907, B*4435, Cw*0206, Cw*0506, and confirmation of A*3106, B*3924, Cw*0314, DRB1*0322, and DRB1*1433 alleles

Tissue Antigens. 2004 Jan;63(1):80-4. doi: 10.1111/j.1399-0039.2004.00146.x.

Abstract

A number of HLA alleles have been newly identified. This concerns HLA-A*0310, A*2907, B*4435, Cw*0206, Cw*0506, of which Cw*0206 was found in three unrelated individuals, all B*4002 positive. Some other alleles are also presented but confirm earlier detected sequences: A*3106, Cw*0314, DRB1*0322, and DRB1*1433. Moreover, we identified B*3924 in a bone marrow transplant recipient and in five of six unrelated stem cell donors, selected for this patient. In all cases, B*3924 was found on a haplotype combining A*0201, B*3924, Cw*0701, and DRB1*1303. The observation of this extended haplotype is of importance for the selection for stem cell transplantation. Cells expressing B*3924 and B*4435 were typed by serology as B39 and B44, respectively. Cells expressing HLA-A*0310 do not express A3 but type as A-Blank.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Bone Marrow Transplantation
  • HLA Antigens / genetics*
  • HLA Antigens / immunology
  • Haplotypes / genetics*
  • Histocompatibility Testing*
  • Humans
  • Linkage Disequilibrium / genetics*

Substances

  • HLA Antigens