The aim of the work was evaluation of influence of infectious process before and in first few days of cerebral infarction on concentrations of acute phase proteins (APP). We evaluated also dynamics of changes of APP and correlation between infection and clinical status and size of ischemia. We examined 47 sick: 30 without infections and 17 with infectious process. Concentrations of C-reactive protein (CRP) and fibrinogen in serum were estimated on 1, 3 and 7 day of infarction. Fisher's scale was used to evaluate patients' clinical status. Comparing to patients without infection, in patients with infection, concentrations of CRP and fibrinogen were higher in all days of investigation but dynamic of changes was different. The highest concentrations of APP in patients without infection were observed on 3 day of infarction (CRP 3.55 +/- 6.76 mg/dl, fibrinogen 425.7 +/- 117.9 mg/dl). In group with infection APP gradually increased and was highest on 7 day (CRP 7.91 +/- 9.28 mg/dl, fibrinogen 422 +/- 119.5 mg/dl). Clinical status of patients with infection compare to patients without infection was heavier and the ischemic focus was larger. Infectious process coexisting witch infectious process influences on deterioration of clinical status and intensifies neurological disorders.