Abstract
The absolute stereostructure of komodoquinone A (1), a neuritogenic anthracycline, which was isolated from a cultured marine Streptomyces sp. KS3, has been determined on the basis of chemical derivatization. Komodoquinone A (1) induces neuronal cell differentiation in the neuroblastoma cell line, Neuro 2A and arrests the cell cycle at the G1 phase. The effect of a solid-state medium on the production of 1 and its aglycone, komodoquinone B (2), was examined.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthracyclines / chemistry*
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Anthracyclines / isolation & purification
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Anthracyclines / pharmacology
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Anthraquinones / chemistry*
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Anthraquinones / isolation & purification
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Anthraquinones / pharmacology
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Cell Cycle / drug effects
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Cell Cycle / physiology
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Cell Line, Tumor
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Fermentation
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Mice
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Seawater / microbiology
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Stereoisomerism
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Streptomyces / chemistry*
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Streptomyces / growth & development
Substances
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Anthracyclines
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Anthraquinones
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komodoquinone A