Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4511-3. doi: 10.1016/j.bmcl.2003.08.028.

Abstract

Several novel bicyclic furanopyrimidine deoxy nucleosides have been designed, prepared and evaluated as anti-Varicella Zoster Virus agents. The compounds have long ether side chains. Uniquely amongst compounds of this family to date the present agents show dual anti- (VZV) and human cytomegalovirus (HCMV) activity. The lead compounds inhibit VZV at 10 nM and HCMV at 5 microM.

MeSH terms

  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Bridged Bicyclo Compounds / chemical synthesis*
  • Bridged Bicyclo Compounds / chemistry
  • Bridged Bicyclo Compounds / pharmacology*
  • Cytomegalovirus / drug effects*
  • Drug Design
  • Herpesvirus 3, Human / drug effects*
  • Humans
  • Molecular Conformation
  • Molecular Structure
  • Pyrimidines / chemical synthesis*
  • Pyrimidines / chemistry
  • Pyrimidines / pharmacology*
  • Structure-Activity Relationship

Substances

  • Antiviral Agents
  • Bridged Bicyclo Compounds
  • Pyrimidines