No evidence for a seriously increased malignancy risk in LGI1-caused epilepsy

Epilepsy Res. 2003 Oct;56(2-3):205-8. doi: 10.1016/j.eplepsyres.2003.09.006.

Abstract

The Leucine-rich Glioma Inactivated-1 (LGI1) gene is supposed to be a tumor suppressor gene involved in glial tumors. Mutations in this gene were recently found to cause autosomal dominant lateral temporal lobe epilepsy (ADLTE). We have now analysed the comorbidity in a large Norwegian ADLTE family. No evidence was found that LGI1 is a high-penetrance tumor suppressor gene associated with a serious risk for malignancies in ADLTE families.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Epilepsy, Temporal Lobe / genetics*
  • Family
  • Female
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Middle Aged
  • Mutation / genetics
  • Neoplasms / epidemiology*
  • Neoplasms / genetics*
  • Proteins / genetics*
  • Risk Assessment

Substances

  • Intracellular Signaling Peptides and Proteins
  • LGI1 protein, human
  • Proteins