Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways

Biochem Soc Trans. 2003 Dec;31(Pt 6):1216-9. doi: 10.1042/bst0311216.

Abstract

S1P (sphingosine 1-phosphate) is the ligand for a family of specific G-protein-coupled receptors that regulate a wide variety of important cellular functions, including vascular maturation, angiogenesis, cell growth, survival, cytoskeletal rearrangements and cell motility. However, S1P also may have intracellular functions. In this review, we discuss two examples that clearly indicate that intracellularly generated and exogenous S1P can regulate biological processes by divergent pathways.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biopterins / analogs & derivatives*
  • Biopterins / biosynthesis
  • Cell Division
  • Cell Line, Tumor
  • Cell Survival
  • Glioma / metabolism
  • Glioma / pathology
  • Humans
  • Lysophospholipids / biosynthesis
  • Lysophospholipids / metabolism*
  • Receptors, G-Protein-Coupled / physiology
  • Receptors, Lysophospholipid
  • Sphingosine / analogs & derivatives
  • Sphingosine / biosynthesis
  • Sphingosine / metabolism*
  • Tumor Necrosis Factor-alpha / physiology

Substances

  • Lysophospholipids
  • Receptors, G-Protein-Coupled
  • Receptors, Lysophospholipid
  • Tumor Necrosis Factor-alpha
  • Biopterins
  • sphingosine 1-phosphate
  • sapropterin
  • Sphingosine