Abstract
Urinary nitrite and F(2)-isoprostanes, an index of oxidant stress, were elevated during chlamydial genital infection of mice. Enhancement of urinary nitrite and F(2)-isoprostanes was observed in phagocyte oxidase-deficient mice. Inhibition of inducible nitric oxide synthase reduced isoprostane excretion. We conclude that nitrogen radicals induce F(2)-isoprostane production and excretion during murine chlamydial genital infection.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Chlamydia Infections / microbiology
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Chlamydia Infections / physiopathology
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Chlamydia trachomatis / pathogenicity*
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F2-Isoprostanes / urine*
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Female
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Gene Expression Regulation*
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Nitric Oxide Synthase / metabolism*
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Nitric Oxide Synthase Type II
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Nitrites / urine*
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Oxidoreductases / genetics
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Phagocytes / enzymology
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Vaginosis, Bacterial / microbiology
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Vaginosis, Bacterial / physiopathology*
Substances
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F2-Isoprostanes
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Nitrites
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Oxidoreductases
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type II
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Nos2 protein, mouse