Synthesis and hypolipidemic activity of N-substituted phthalimides. Part V

Vera L M Sena; Rajendra M Srivastava; Ricardo O Silva; Vera L M Lima

doi:10.1016/S0014-827X(03)00185-X

Synthesis and hypolipidemic activity of N-substituted phthalimides. Part V

Farmaco. 2003 Dec;58(12):1283-8. doi: 10.1016/S0014-827X(03)00185-X.

Authors

Vera L M Sena¹, Rajendra M Srivastava, Ricardo O Silva, Vera L M Lima

Affiliation

¹ Departamento de Química Fundamental, Universidade Federal de Pernambuco (UFPE), Av. Luis Freire, S/N, Cidade Universitária, CEP 50.740-540 Recife, PE, Brazil.

PMID: 14630240
DOI: 10.1016/S0014-827X(03)00185-X

Abstract

A series of N-aryl- or N-(1,2,4-triazol-yl)-phthalimides (4a-4i) have been synthesized starting from phthalic anhydride (1) and an appropriate amine (2a-2i). All compounds presented hypolipidemic activity, but compound 4d proved to be the most active and reduced plasma cholesterol and triglyceride levels in Swiss white mice significantly.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anticholesteremic Agents / chemical synthesis
Anticholesteremic Agents / pharmacology
Cholesterol / blood
Hypolipidemic Agents / chemical synthesis*
Hypolipidemic Agents / pharmacology*
Mice
Phthalimides / chemical synthesis*
Phthalimides / pharmacology*
Triglycerides / blood

Substances

Anticholesteremic Agents
Hypolipidemic Agents
Phthalimides
Triglycerides
Cholesterol