The early experiences using ultrasound-assisted liposuction in treating difficult fibrous cases, such as gynecomastia, have led to the evolution and improvement of ultrasound-assisted liposuction techniques. This prospective study examined 348 consecutive patients treated with ultrasound-assisted liposuction over two and a half years, from October of 1998 to July of 2001. We use a three-stage technique consisting of infiltration, ultrasound-assisted sculpturing, and suction-assisted liposuction. This technique has improved our final outcome, with better skin contraction, shorter operative time, and minimization of complications, resulting in the optimization of liposuction as a safe procedure.