Total synthesis and reassessment of the phosphatase-inhibitory activity of the antitumor agent TMC-69-6H

Angew Chem Int Ed Engl. 2003 Nov 10;42(43):5361-4. doi: 10.1002/anie.200352268.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Catalysis
  • Cell Cycle Proteins / chemical synthesis*
  • Hydrogenation
  • Inhibitory Concentration 50
  • Isoenzymes / antagonists & inhibitors
  • Nitrophenols / chemistry
  • Organophosphorus Compounds / chemistry
  • Oxidation-Reduction
  • Palladium
  • Pyrans / chemical synthesis*
  • Stereoisomerism
  • Structure-Activity Relationship
  • cdc25 Phosphatases / antagonists & inhibitors*

Substances

  • Antineoplastic Agents
  • Cell Cycle Proteins
  • Isoenzymes
  • Nitrophenols
  • Organophosphorus Compounds
  • Pyrans
  • TMC-69-6H
  • nitrophenylphosphate
  • Palladium
  • cdc25 Phosphatases