Isolation of bisindole alkaloids that inhibit the cell cycle from Myxomycetes Arcyria ferruginea and Tubifera casparyi

Bioorg Med Chem Lett. 2003 Sep 1;13(17):2879-81. doi: 10.1016/s0960-894x(03)00592-4.

Abstract

From a myxomycete Arcyria ferruginea, dihydroarcyriarubin C (1), a new bisindole alkaloid, has been isolated together with two known bisindoles, arcyriarubin C (2) and arcyriaflavin C (3), and arcyriaflavin C (3) was also isolated from Tubifera casparyi together with arcyriaflavin B (4). Arcyriaflavin C (3) exhibited cell cycle inhibition effect at G1 and G2/M stage at 10 and 100ng/mL, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Cycle / drug effects*
  • DNA / analysis
  • G1 Phase / drug effects
  • G2 Phase / drug effects
  • HeLa Cells
  • Humans
  • Indole Alkaloids / chemistry
  • Indole Alkaloids / isolation & purification*
  • Indole Alkaloids / pharmacology*
  • Myxomycetes / chemistry*
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • Indole Alkaloids
  • arcyriaflavin C
  • DNA