Abstract
Myxovirus A (MxA) is a protein that is specifically induced by treatment with type I cytokines and has proven to be a reliable biomarker of interferon-beta (IFNbeta) bioactivity. IFNbeta-induced MxA can be measured as either protein or mRNA in the blood of IFNbeta-treated patients with MS. In patients with MS who are treated with IFNbeta, loss of the MxA response is caused by high levels of anti-IFNbeta antibodies and is a sensitive marker of lost bioactivity.
MeSH terms
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Biological Availability
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Biomarkers / analysis
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Biomarkers / blood
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Blood Cells / chemistry
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Drug Resistance / immunology
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Enzyme-Linked Immunosorbent Assay
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GTP-Binding Proteins / analysis*
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GTP-Binding Proteins / genetics
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Humans
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Interferon-beta / immunology*
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Interferon-beta / pharmacokinetics
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Interferon-beta / therapeutic use
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Multiple Sclerosis / blood
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Multiple Sclerosis / drug therapy
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Multiple Sclerosis / immunology
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Myxovirus Resistance Proteins
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RNA, Messenger / analysis*
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Reproducibility of Results
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Reverse Transcriptase Polymerase Chain Reaction
Substances
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Biomarkers
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MX1 protein, human
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Myxovirus Resistance Proteins
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RNA, Messenger
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Interferon-beta
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GTP-Binding Proteins