Measurement of MxA mRNA or protein as a biomarker of IFNbeta bioactivity: detection of antibody-mediated decreased bioactivity (ADB)

Neurology. 2003 Nov 11;61(9 Suppl 5):S24-6. doi: 10.1212/01.wnl.0000092361.04511.d0.

Abstract

Myxovirus A (MxA) is a protein that is specifically induced by treatment with type I cytokines and has proven to be a reliable biomarker of interferon-beta (IFNbeta) bioactivity. IFNbeta-induced MxA can be measured as either protein or mRNA in the blood of IFNbeta-treated patients with MS. In patients with MS who are treated with IFNbeta, loss of the MxA response is caused by high levels of anti-IFNbeta antibodies and is a sensitive marker of lost bioactivity.

Publication types

  • Review

MeSH terms

  • Biological Availability
  • Biomarkers / analysis
  • Biomarkers / blood
  • Blood Cells / chemistry
  • Drug Resistance / immunology
  • Enzyme-Linked Immunosorbent Assay
  • GTP-Binding Proteins / analysis*
  • GTP-Binding Proteins / genetics
  • Humans
  • Interferon-beta / immunology*
  • Interferon-beta / pharmacokinetics
  • Interferon-beta / therapeutic use
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / drug therapy
  • Multiple Sclerosis / immunology
  • Myxovirus Resistance Proteins
  • RNA, Messenger / analysis*
  • Reproducibility of Results
  • Reverse Transcriptase Polymerase Chain Reaction

Substances

  • Biomarkers
  • MX1 protein, human
  • Myxovirus Resistance Proteins
  • RNA, Messenger
  • Interferon-beta
  • GTP-Binding Proteins