New silica-immobilized chiral amino alcohol for the enantioselective addition of diethylzinc to benzaldehyde

José M Fraile; José A Mayoral; Jorge Serrano; Miquel A Pericàs; Lluís Solà; David Castellnou

doi:10.1021/ol0355985

New silica-immobilized chiral amino alcohol for the enantioselective addition of diethylzinc to benzaldehyde

Org Lett. 2003 Nov 13;5(23):4333-5. doi: 10.1021/ol0355985.

Authors

José M Fraile¹, José A Mayoral, Jorge Serrano, Miquel A Pericàs, Lluís Solà, David Castellnou

Affiliation

¹ Departamento de Química Orgánica, Instituto de Ciencia de Materiales de Aragón, Facultad de Ciencias, Universidad de Zaragoza-CSIC, E-50009 Zaragoza, Spain.

PMID: 14601993
DOI: 10.1021/ol0355985

Abstract

[reaction: see text] A readily available chiral amino alcohol has been immobilized on silica by sol-gel synthesis and grafting. The solid prepared according to the latter method led to the best enantioselectivity (77% ee) described for the asymmetric addition of diethylzinc to benzaldehyde using inorganic solids.