Abstract
Five compounds have been isolated from the dried whole plants of Selaginella uncinata, two of them were new chromone glycosides, 5-hydroxy-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside (uncinoside A) and 5-acetoxyl-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside (uncinoside B). Their structures were elucidated by spectroscopic methods including one- and two-dimensional NMR techniques. The other three compounds were identified as 8-methyl eugenitol, amentoflavone and hinokiflavone. Uncinoside A and B showed potent antiviral activities against respiratory syncytial virus (RSV) with IC(50) value of 6.9 and 1.3 microg/ml, moderate antiviral activities against parainfluenza type 3 virus (PIV 3) with IC(50) value of 13.8 and 20.8 microg/ml, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / isolation & purification*
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Antiviral Agents / pharmacology*
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Cell Survival / drug effects
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Chromones / isolation & purification*
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Chromones / pharmacology*
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Crystallography, X-Ray
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Cytopathogenic Effect, Viral / drug effects
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Hydrolysis
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Conformation
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Parainfluenza Virus 3, Human / drug effects
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Respiratory Syncytial Viruses / drug effects
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Selaginellaceae / chemistry*
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Virus Replication / drug effects
Substances
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5-acetoxyl-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside
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5-hydroxy-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside
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Antiviral Agents
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Chromones
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Plant Extracts