In vitro activity of recombinant lysostaphin against Staphylococcus aureus isolates from anterior nares and blood

Christof von Eiff; John F Kokai-Kun; Karsten Becker; Georg Peters

doi:10.1128/AAC.47.11.3613-3615.2003

In vitro activity of recombinant lysostaphin against Staphylococcus aureus isolates from anterior nares and blood

Antimicrob Agents Chemother. 2003 Nov;47(11):3613-5. doi: 10.1128/AAC.47.11.3613-3615.2003.

Authors

Christof von Eiff¹, John F Kokai-Kun, Karsten Becker, Georg Peters

Affiliation

¹ Institute of Medical Microbiology, University of Münster Hospital and Clinics, 48149 Muenster, Germany. eiffc@uni-muenster.de

Abstract

The in vitro activity of recombinant lysostaphin was tested against a collection of well-characterized clinical Staphylococcus aureus isolates by disk diffusion (429 isolates) and minimum bactericidal concentration (10 isolates) assays. Minimum bactericidal concentrations of 0.16 microg/ml and zones of inhibition ranging between 15 and 21 mm in diameter demonstrate that lysostaphin was highly active against all isolates tested.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Bacteremia / microbiology
Carrier State / microbiology
Humans
Lysostaphin / pharmacology*
Microbial Sensitivity Tests
Nasal Mucosa / microbiology*
Recombinant Proteins / pharmacology
Staphylococcal Infections / blood
Staphylococcal Infections / microbiology*
Staphylococcus aureus / drug effects*

Substances

Anti-Bacterial Agents
Recombinant Proteins
Lysostaphin