Abstract
Incorporation studies with 13C-, 15N-, and 2H-labeled substrates, followed by NMR analysis, show that the pyrimidine unit of thiamin (Vitamin B1) originates from a C5N fragment, derived from C-2',2,N,C-6,5,5' of pyridoxol (Vitamin B6) and an N-C-N fragment derived from L-histidine. Urocanic acid serves as an intermediate on the route of the N-C-N fragment of histidine into the thiamin pyrimidine.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Candida / metabolism*
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Glucose / metabolism
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Glycerol / metabolism
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Histidine / metabolism*
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Nuclear Magnetic Resonance, Biomolecular
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Pyridines / metabolism*
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Pyridoxine / metabolism*
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Saccharomyces cerevisiae / metabolism*
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Thiamine / biosynthesis*
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Thiamine / metabolism
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Urocanic Acid / metabolism*
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Vitamin B 6 / metabolism
Substances
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Pyridines
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Histidine
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Vitamin B 6
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Urocanic Acid
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Glucose
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Pyridoxine
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pyridine
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Glycerol
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Thiamine