Synthesis of new homo and heterodimers of 2',3'-dideoxyinosine (ddI) using ester linkages

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):829-31. doi: 10.1081/NCN-120022664.

Abstract

A series of new homo and heterodimers of ddI has been synthesized. A glutarate diester spacer was used to covalently couple ddI onto ddI, AZT or d4T.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemistry
  • Didanosine / analogs & derivatives*
  • Didanosine / chemical synthesis
  • Didanosine / chemistry*
  • Dimerization
  • Esters
  • Indicators and Reagents
  • Molecular Conformation
  • Stavudine / chemistry
  • Zidovudine / chemistry

Substances

  • Anti-HIV Agents
  • Esters
  • Indicators and Reagents
  • Zidovudine
  • Stavudine
  • Didanosine