Synthesis of carbocyclic analogues of MECA and NECA 1,2-disubstituted as potential adenosine receptor agonists

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):759-61. doi: 10.1081/NCN-120022628.

Abstract

A new class of 1,2-disubstituted carbocyclic nucleosides of MECA and NECA analogues was synthesized in good yield starting from (+/-) 6-azabicyclo[3.2.0]heptan-7-one.

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / chemical synthesis*
  • Adenosine / chemistry
  • Adenosine-5'-(N-ethylcarboxamide) / analogs & derivatives*
  • Adenosine-5'-(N-ethylcarboxamide) / chemical synthesis*
  • Indicators and Reagents
  • Models, Molecular
  • Molecular Conformation
  • Purinergic P1 Receptor Agonists*
  • Purines / chemical synthesis

Substances

  • Indicators and Reagents
  • Purinergic P1 Receptor Agonists
  • Purines
  • 5'-N-methylcarboxamideadenosine
  • Adenosine-5'-(N-ethylcarboxamide)
  • Adenosine