Properties of triple helices formed by oligonucleotides containing 8-aminopurines

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):645-8. doi: 10.1081/NCN-120021971.

Abstract

The synthesis of parallel hairpins carrying 8-aminopurines is described. These hairpins have a high affinity for specific polypyrimidine sequences resulting in the formation of very stable triplexes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Models, Molecular
  • Nucleic Acid Conformation
  • Nucleic Acid Denaturation
  • Oligodeoxyribonucleotides / chemical synthesis
  • Oligodeoxyribonucleotides / chemistry*
  • Purines / chemistry*
  • Thermodynamics

Substances

  • Oligodeoxyribonucleotides
  • Purines