Abstract
The recently described structure of bone morphogenetic protein 7 in complex with the extracellular domain of the activin type receptor II provides a new and important paradigm to add to the list of possible modes of receptor assembly. A new mode of a ligand-mediated cooperative receptor assembly without receptor-receptor contacts yields new and exciting insights into the molecular signal transduction mechanism in the transforming growth factor-beta superfamily.
MeSH terms
-
Activin Receptors, Type II / metabolism*
-
Animals
-
Bone Morphogenetic Protein 7
-
Bone Morphogenetic Proteins / metabolism*
-
Cell Membrane / metabolism
-
Kinetics
-
Ligands
-
Models, Biological
-
Protein Binding
-
Protein Structure, Secondary
-
Protein Structure, Tertiary
-
Transforming Growth Factor beta / metabolism
Substances
-
Bone Morphogenetic Protein 7
-
Bone Morphogenetic Proteins
-
Ligands
-
Transforming Growth Factor beta
-
Activin Receptors, Type II
-
activin receptor type II-A