Rabs, Rips, FIPs, and endocytic membrane traffic

ScientificWorldJournal. 2003 Sep 15:3:870-80. doi: 10.1100/tsw.2003.69.

Abstract

Rab GTPases, proteins belonging to the Ras-like small GTP-binding protein superfamily, have emerged as master regulators of cellular membrane transport. Rab11 GTPase, a member of the Rab protein family, plays a role in regulating various cellular functions, including plasma membrane recycling, phagocytosis, and cytokinesis. Rab11 acts by forming mutually exclusive complexes with Rab11-family binding proteins, known as FIPs. Rab11-FIP complexes serve a role of "targeting complexes" by recruiting various membrane traffic factors to cellular membranes. Recent studies have identified several Rab11-FIP complex-binding proteins that regulate distinct membrane traffic pathways.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Amino Acid Sequence
  • Animals
  • Carrier Proteins / chemistry
  • Carrier Proteins / classification
  • Carrier Proteins / metabolism*
  • Cell Membrane / metabolism*
  • Endocytosis*
  • Humans
  • Membrane Proteins / chemistry
  • Membrane Proteins / classification
  • Membrane Proteins / metabolism*
  • Mitochondrial Proteins*
  • Molecular Sequence Data
  • Protein Transport
  • rab GTP-Binding Proteins / metabolism*

Substances

  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • Membrane Proteins
  • Mitochondrial Proteins
  • RAB11FIP5 protein, human
  • RAB11FIP2 protein, human
  • rab GTP-Binding Proteins