Antiviral activity of 2-amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one on poliovirus

Akiko Iwata; Teruhide Yamaguchi; Kouei Sato; Ryutaro Izumi; Akio Tomoda

doi:10.1620/tjem.200.161

Antiviral activity of 2-amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one on poliovirus

Tohoku J Exp Med. 2003 Jul;200(3):161-5. doi: 10.1620/tjem.200.161.

Authors

Akiko Iwata¹, Teruhide Yamaguchi, Kouei Sato, Ryutaro Izumi, Akio Tomoda

Affiliation

¹ Division of Cellular and Gene Therapy Products, National Institute of Health Sciences, Tokyo 158-0098, Japan.

PMID: 14521260
DOI: 10.1620/tjem.200.161

Abstract

2-Amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one (Phx), which was produced by the reaction of bovine hemoglobin with 2-amino-5-methylphenol, inhibited the proliferation of poliovirus in Vero cells between 0.25 microg/ml and 2 microg/ml with maximal antiviral acitivity at 1 microg/ml. These results suggest that Phx may be useful to prevent the proliferation of poliovirus infection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiviral Agents / pharmacology
Antiviral Agents / toxicity
Cell Survival / drug effects
Chlorocebus aethiops
Cytopathogenic Effect, Viral / drug effects
Dose-Response Relationship, Drug
Oxazines / pharmacology*
Oxazines / toxicity
Poliovirus / drug effects*
Poliovirus / growth & development
Vero Cells

Substances

2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3-one
Antiviral Agents
Oxazines