Effect of prednisone priming followed by alfa-interferon in treatment of children with chronic hepatitis B: an interim analysis of a controlled trial

R Utili; E Sagnelli; G Giusti; G Ruggiero; F Piccinino; B Galanti; L E Adinolfi; L Aprea; G Cesaro; L Digilio

doi:10.1007/978-3-7091-5633-9_62

Effect of prednisone priming followed by alfa-interferon in treatment of children with chronic hepatitis B: an interim analysis of a controlled trial

Arch Virol Suppl. 1992:4:277-80. doi: 10.1007/978-3-7091-5633-9_62.

Authors

R Utili¹, E Sagnelli, G Giusti, G Ruggiero, F Piccinino, B Galanti, L E Adinolfi, L Aprea, G Cesaro, L Digilio, et al.

Affiliation

¹ Clinic of Infectious Diseases and Tropical/Subtropical Diseases, 1st Medical School University of Naples, Italy.

PMID: 1450701
DOI: 10.1007/978-3-7091-5633-9_62

Abstract

A six-month analysis of a controlled trial on the treatment of chronic hepatitis B in children shows that prednisone priming followed by alpha-interferon 2A was effective in 6 of 9 treated patients in reducing HBV replication and disease activity.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Child
Drug Therapy, Combination
Female
Hepatitis B / therapy*
Hepatitis B virus / drug effects
Hepatitis B virus / growth & development
Hepatitis, Chronic / therapy*
Humans
Interferon alpha-2
Interferon-alpha / therapeutic use*
Male
Prednisone / therapeutic use*
Prospective Studies
Recombinant Proteins
Treatment Outcome
Virus Replication / drug effects

Substances

Interferon alpha-2
Interferon-alpha
Recombinant Proteins
Prednisone